SUKHOTNIK IGOR
PERSONAL DETAILS
Date and Place of Birth: September 28, 1962, Chernovtsy, Ukraine
Date of Immigration: October 23, 1989
Family status: Married + 3
E-mail: igor-dr@internet-zahav.net
EDUCATION
1979-1985 M.D. University of Medicine ,Chernovtsy, Ukraine
1986-1989 Residency, General Surgery, University Hospital, Chernovtsy, Ukraine
1989-1998 Residency, Pediatric Surgery, Ha-Emek Medical Center, Afula, Israel
2000-2003 Residency, General Surgery, Carmel Medical Center, Haifa, Israel
ACADEMIC APPOINTMENTS
2013-Present Associate Professor, Technion- Israel Institute of Technology, Haifa 2005-2013 Senior Lecturer (Assistant Professor), Technion - Israel Institute of Technology, Haifa 2003-2004 Clinical Instructor, Bnai Zion Medical Center, Technion, Haifa
2000-2002 Clinical Instructor, Carmel Medical Center, Technion, Haifa
POSTGRADUATE PROFESSIONAL EXPERIENCE
2013-Present Head Dept Pediatric Surgery in Charge, Bnai Zion Medical Center, Haifa.
2003-2013 Tenured Senior Pediatric Surgeon, Bnai Zion Medical Center, Haifa.
2009-2010 Visiting Professor, Division of Pediatric Surgery, Lucile Packard Children's
Hospital, Stanford University, California.
2004 Course "Minimally Invasive Techniques in Pediatrc Surgery", Hamburg, Germany
2000-2003 Resident, General Surgery, Dept. Surgery B, Carmel Medical Center, Haifa.
1999-2000 Postdoctoral training and research fellowship, Mott Children’s Hospital, University of Michigan, USA.
1997-1999 Tenured Senior Pediatric Surgeon, Ha-Emek Medical Center, Afula.
1990-1997 Resident, Pediatric Surgery, Ha-Emek Medical Center, Afula.
1986-1989 Resident, General Surgery, University Hospital, Chernovtsy, Ukraine.
1985-1986 Rotating Internship, University Hospital, Chernovtsy, Ukraine.
RESEARCH INTERESTS
1. Issue “ Short bowel syndrome”
2. Issue “Lypopolisacharide endotoxemia and bowel integrity”
3. Issue “Intestinal ishemia-reperfusion”
4. Issue “Apoptosis and germ cells in infertility”
5. Issue “ Abdominal compartment syndrome”
6. Issue "Chemotherapy induced intestinal damage"
7. Issue "Intestinal stem cells"
TEACHING EXPERIENCE
2000-2003 Instructor, Course “Introduction to medicine", Carmel Medical Center and Bnai Zion Medical Center, Technion, Israel institute of technology, Haifa, Israel
2000-2004 Cinical instructor undergraduate medical students, general and pediatric surgery, Carmel Medical Center and Bnai Zion Medical Center, Technion, Israel institute of technology, Haifa Israel
2005- present Cinical instructor undergraduate medical students, Clerkship, Pediatric Surgery, Bnai Zion Medical Center Haifa,Israel 2005- present Cinical instructor undergraduate medical students, Course: Clinical Nutrition in
Surgery.
TECHNION ACTIVITIES
2007-present Rappaport Faculty of Medicine Institutional Animal Care and Use Committee.
2008-present Rappaport Faculty of Medicine Institutional MD Thesis committee
2005-2008 Responsible for Institutional Board Exam of Surgery
PUBLIC PROFESSIONAL ACTIVITIES
Professional Activity 2011-2014- Israeli Society of Pediatric Surgery, Secretary
Editorial Boards
Open Journal of Gastroenterology, Editorial Board World Journal of Gastroenterology, Editorial Board International Journal of Pediatric Research, Editorial Board
Reviewer
Reviewer, Gut
Reviewer, Journal of the American College of Nutrition Reviewer, Journal of Endocrinological Investigation Reviever, Medical Science Monitor Reviever, Nitric Oxide
Reviewer, Apoptosis
Reviewer, European Journal of Clinical Nutrition
Reviewer, Nature Clinical Practice Gastroenterology&Hepatology
Reviewer, Life Sciences
Reviewer, Nutrition
Reviewer, European Surgical Research Reviewer, Inflammation Research Reviewer, Journal of Immunology Reviewer, Regulatory Peptides Reviewer, Cancer Chemotherapy and Pharmacology Reviewer, Journal of Interferon & Cytokine Research Reviewer, Journal of Pediatric Surgery Reviewer, Indian Journal of Pediatrics Reviewer, European Journal of Physiology Reviewer, American Journal of Physiology Reviewer, British Journal of Nutrition Reviewer, Expert Opinion On Pharmacotherapy Reviewer, Asian Journal of Andrology Reviewer, Scandinavian Journal of Gastroenterology
Reviewer, PLoS One Reviewer, FASEB Journal
MEMBERSHIP IN PROFESSIONAL SOCIETIES
NATIONAL
Israeli Medical Association
Israeli Association of Pediatric Surgeons
Israeli Association of Pediatrics
Israeli Association of Clinical Pediatrics
INTERNATIONAL
European Pediatric Surgeons' Association
Fellow American College of Surgeons (FACS)
Member of the Scientific Office of EUPSA (European Pediatric Surgery Association).
STUDENTS and INSTRUCTION
Graduate Students
2007-2010 Voskoboinik Katia, Magister Degree
Mechanism of germ cell apoptosis in ischemic and contralateral testes following testicular ischemia- reperfusion in a rat. Co-Supervisor: Dr. J. Mogilner
2008-2010 Shani Ben-Lulu , Magister Degree
Effect of peptide growth factors on intestinal recovery and enterocyte turnover after chemotherapy induced intestinal injury in a rat. Co-Supervisor: Dr. J. Mogilner
2010-Present Goldshmidt Maria, Magister Degree
Evaluation of signaling cascades (Wnt, Hedgehog, BMP and Notch) implicated in the control of stem cell activities after massive small bowel resection in a rat model.
MD Thesis
2001 Khateeb Kamal. Sandostatin impairs post-resection intestinal adaptation in a rat model of short bowel syndrome. MD Thesis. 2005 Alenberg Igal. The effect of dexamethasone on germ cell apoptosis following testicular ischemia-reperfusion in rat. MD Thesis. Co-Supervisor: Dr. J. Mogilner. 2006 Modi Agam. The effect of enteral glutamine supplementation on intestinal structural
changes, enterocyte proliferation, and apoptosis following LPS endotoxemia in rat. MD Thesis. Co- Supervisor: Dr. J. Mogilner.
2007 Egosy Tomer.Effect of Leptin in preventing intestinal injury caused by methotrexate in a rat model. MD Thesis. Co-Supervisor: Dr. J. Mogilner.
2008 Anette Shani. Effect of Omega 3 fatty acids (enteral vs paraenteral) on intestinal adaptation after massive small resection in a rat. MD Thesis. Co-Supervisor: Dr. R. Shaoul.
Basic Science
2002 Khateeb Kamal. The role of enteral glutamine in preventing mucosal injury and intestinal recovery following intestinal ischemia reperfusion in rats. 2007 Kochanovsky Nataly. Effect of glutamine in preventing intestinal injury caused by methotrexate in a rat model.
2007 Slijper Nadav. Effect of TGF-alpha on intestinal adaptation in a rat model of short bowel syndrome. Co-Supervisor: Dr. J. Mogilner.
2008 Gil Mayer. Effect of allopurinol on germ cell apoptosis following testicular ischemia- reperfusion in a rat model. Co-Supervisor: Dr. J. Mogilner. 2009 Gadzaev Galina. Effect of TGF-alpha in preventing mucosal damage caused by methotrexate in a rat model. Co-Supervisor: Dr. J. Mogilner. 2009 Shteinberg Dan. Effect of transforming growth factor α in preventing gut injury caused by methotrexate in a rat model. 2010 Blumenfeld Shiri. Platelet-derived growth factor-alpha (PDGF-α) stimulates intestinal epithelial cell turnover after massive small bowel resection in a rat.
2011 Razon Hila. Effect of alpha-naphthylisothiocyanate induced liver injury on intestinal adaptation in a rat model of short bowel syndrome. 2011 Janna Pilatov. Effect of glutamine on Toll-like receptor signaling during intestinal injury caused by methotrexate in a rat model. 2011 Dorfman Tatiana. Effect of insulin on Wnt/beta-catenin signaling implicated in the control of stem cell activities in diabetes-induced enteropathy in a rat model. 2012 Borisovsky Nina. Evaluation of Notch signaling cascade implicated in the control of stem cell activities after massive small bowel resection in a rat model.
2013 Yuri Brodsky . Role of Wnt/beta-catenin signaling cascade during intestinal adaptation after massive small bowel resection in a rat model.
2014 Gayer Tatiana. Effect of methotrexate on Wnt/beta-catenin signaling implicated in the control of stem cell activities during chemotherapy-induced mucositis in a rat model.
2014 Haj Bassel. Effect of ozone on intestinal recovery following gut ischemia-reperfusion injury in a rat.
RESEARCH GRANTS
2007-2008 100,000 EURO /2 years
VFK Krebsforschung gGmbH research grant, Berlin , Germany
Effect of peptidegrowth factors on intestinal recovery and enterocyte turnover after chemotherapy induced intestinal injury in a rat.
Principal Investigator.
2009-2011 153,000 $ / 3 years
Israel Science Foundation (ISF) Research Grant
Effect of peptide growth factors on enterocyte turnover in a rat model of short bowel syndrome.
Principal Investigator (CI- Dr Mogilner)
2010-2012 300,000NIS / 2 years
Israel Ministry of Health Foundation Research Grant
Effect of immunonutrition and dietary supplementation with TGFβ on intestinal recovery following chemotherapy-induced intestinal damage in a rat model. Principal Investigator.
HONORS
PRIZES AND AWARDS
Effect of low fat diet on CD36 expression in small bowel and long chain fatty acid uptake by isolated enterocyte in rats following bowel resection. 13th Annual International Congress: Research in Pediatric Surgery, Ann Arbor, MI, November 2000
Second Novartis prize for research work presentation
Low Fat Diet inhibits adaptation in a rat following bowel resection. The 22nd Israel Surgical Federation National Congress,Tel Aviv,Israel. May, 2001.
Prize for best research work presentation in the name of Prof. Erlich R.I.P.
Arginine inhibits adaptation in a rat following bowel resection. Technion- Israel Institute of Technologi, Rappaport Faculty of Medicine. May, 2003.
Second Prize for best work in surgical reseatch in the name of Prof. Barzilai
Effect of eleveted intraabdominal pressure on intestinal structure and bacterial translocation in rat. 13th Annual Congress for Endosurgery in Children, Maui, Hawaii. May, 2004.
First Prize for best research work presentation
Effect of subcutaneous insulin on intestinal adaptation in a rat model of short bowel syndrome. 17th International Symposium of Pediatric Surgical Research, Liverpool, UK. October, 2004.
First Novartis Prize for best research work presentation
Leptin stimulates intestinal re-growth following massive small bowel resection in a rat. 18th International Symposium of Pediatric Surgical Research, Stockholm, Sweden September, 2005.
Second Novartis Prize for research work presentation 7
Bombesin stimulates enterocyte turnover following massive small bowel resection in a rat. 19th International Symposium of Pediatric Surgical Research, Florence, Italy October, 2006.
Third Novartis Prize for research work presentation
Responsiveness of intestinal epithelial cell turnover to TGF- α after bowel resection in a rat is correlated with EGF receptor expression along the villus-crypt axis. 20th International Symposium of Pediatric Surgical Research. Bern, Switzerland, October, 2007.
Third Novartis Prize for research work presentation
Oral insulin stimulates intestinal epithelial cell turnover in correlation with insulin-receptor expression along the villus-crypt axis in a rat model of short bowel syndrome. 22nd International Symposium of Pediatric Surgical Research. Genova, Italy September, 2009.
Third Novartis Prize for research work presentation
Parenteral omega-3 fatty acids (Omegaven) modulate intestinal recovery following inestinal ischemia-reperfusion in a rat. The 27th Israel Surgical Federation National Congress, Jerusalem, Israel. June, 2011.
Prize for best research work presentation
PATENTS
METHODS AND FORMULATIONS FOR INCREASING INTESTINAL FUNCTION. U.S. Patent Application No. 13/213,325
LIST OF PUBLICATIONS Basic research 1. Sukhotnik I, Gork AS, Chen M, Drongovski B, Coran AG, Harmon MC. Effect of high fat diet on CD36 expression in small bowel and long chain fatty acid uptake by isolated enterocyte in a rat model of short bowel syndrome. Surgical Forum, 2000, Volume LI, 525-527.
2. Sukhotnik I, A.S.Gork, M.Chen, R.A.Drongovski, A.G.Coran, C.M.Harmon. Effect of low fat diet on lipid absorption and fatty acid transport following bowel resection. Ped Surg International 2001; 17: 259-264.
3. Sukhotnik I, L. Siplovich, E. Shiloni, N. Mor-Vaknin, C. M, Harmon, A.G. Coran. Intestinal adaptation in short bowel syndrome in infants and children. Ped Surg International 2002; 18:258- 263.
4. Sukhotnik I, M.M. Krausz, M. Balan, A.Turkieh, L.Siplovich, H. Bitterman. Divergent effects of 8
oxygen therapy in four models of uncontrolled hemorrhagic shock. Shock 2002, 18:277-284.
5. Sukhotnik I, Khateeb K, Krausz MM, Sabo E, Siplovich L, Coran AG, Shiloni E. Sandostatin impairs post-resection intestinal adaptation in a rat model of short bowel syndrome. Digestive Diseases and Sciences 2002, 47:2095-2102.
6. Sukhotnik I, Gork AS, Chen M, Drongovski B, Coran AG, Harmon MC. Effect of bowel resection and high-fat diet on heart CD36/fatty-acid translocase expression in a rat model of short- bowel syndrome. Pediatr Surg Int 2002; 18:620-623.
7. Sukhotnik I, Yakirevich E, Coran AG, L.Siplovich, Kramer A, Sabo E, Krausz M, Shiloni E. Lipopolysaccharide endotoxemia reduces cell proliferation and decreases enterocyte apopotosis during intestinal adaptation in a rat model of short-bowel syndrome. Pediatr Surg Int 2002; 18:615-619.
8. Sukhotnik I, Yakirevich E, Coran AG, L.Siplovich, Hirsh M, Sabo E, Krausz M, Shiloni E. Effect of transforming growth factor-alpha on intestinal adaptation in a rat model of short bowel syndrome. J Surg Res 2002; 108:235-242.
9. Sukhotnik I, Krausz MM, Sabo E, Resnick M, Hirsh M, Mannheim D, Shiloni E. Endotoxemia inhibits intestinal adaptation in a rat model of short bowel syndrome. Shock 2003; 19:66-70.
10.Sukhotnik I, Gork AS, Drongowski RA, Coran AG, Harmon CM. Effect of high fat diet on lipid absorption and fatty acid transport in a rat model of short bowel syndrome. Pediatr Surg Int 2003, 19: 385-391.
11. Sukhotnik I, Lerner A, Sabo E, Krausz MM, Siplovich L, Coran AG, Mogilner J, Shiloni E. Effects of enteral arginine supplementation on structural intestinal adaptation in a rat model of short bowel syndrome. Digestive Diseases and Sciences 2003; 48:1346-1351.
12. Sukhotnik I, Yakirevich E, Coran AG. Liposaccharide endotoxemia reduces cell proliferation and decreases enterocyte apoptosis during intestinal adaptation in a rat model of short-bowel syndrome. J Pediatr Surg 2003; 38:1123.
13.Sukhotnik I, Shiloni E, Krausz M, Yakirevich E, Sabo E, Mogilner J, Coran AG, Harmon CM. Low fat diet impairs post-resection intestinal adaptation in a rat. J Pediatr Surgery 2003; 38: 1182- 1187.
14.Sukhotnik I, Mor-Vaknin N, Drongowski RA, Coran AG, Harmon CM. Effect of dietary fat on fat absorption and concomitant plasma and tissue fat composition in a rat model of short bowel syndrome. Pediatr Surg Int. 2004; 20:185-191.
15.Sukhotnik I, Coran AG, Harmon CM. Reply. Gastroenterology 2004; 126: 921.
16.Sukhotnik I, Mor-Vaknin N, Drongowski RA, Miselevich I, Coran AG, Harmon CM. Effect of dietary fat on early morphological intestinal adaptation in a rat model of short bowel syndrome. Pediatr Surg Int 2004, 20: 419-424.
17.Sukhotnik I, Mogilner J, Krausz MM, Lurie M, Hirsh M, Coran AG, Shiloni E. Oral arginine reduces gut mucosal injury caused by lipopolysaccharide endotoxemia in a rat. J Surg Res 2004, 122: 256-262. 9
18.Sukhotnik I, Mogilner J, Shamir R, Shehadeh N, Bejar J, Hirsh M, Coran AG. Effect of subcutaneous insulin on intestinal adaptation in a rat model of short bowel syndrome. Pediatr Surg Int 2005, 21: 132-137.
19.Sukhotnik I, Helow H, Mogilner J, Lurie M, Bernsteyn A, Coran AG, Shiloni E. Oral Arginine Reduces Intestinal Mucosal Injury Caused by Ischemia- Reperfusion in Rat. Pediatr Surg Int 2005, 21: 191-196.
20.Sukhotnik I, Shiloni E, Mogilner J, Lurie M, Hirsh M, Coran AG, Krausz MM. Effect of gender and sex hormones on structural intestinal adaptation following massive small bowel resection in a rat. J Pediatr Surg 2005; 40: 489-495.
21.Sukhotnik I, J.G.Mogilner, A. Lerner, A.G.Coran, L.Siplovich, M. Lurie, I.Miselevich, E. Shiloni Parenteral arginine impairs intestinal adaptation following massive small bowel resection in a rat model. Ped Surg Int 2005; 21:460-465.
22.Sukhotnik I, Miselevich I, Lurie M, Nativ O, Coran AG, Mogilner G. The time relationship between ipsilateral testicular ischemia-reperfusion and germ cell apoptosis in the contralateral testis in rat Ped Surg Int 2005, 15; 1-5.
23.Shamir R, Muslach M, Sukhotnik I, Perlman R, Diamond E, Mogilner J, Shehadeh N. Intestinal and systemic effects of oral insulin supplementation in rats after weaning. Dig Dis Sci 2005; 50: 1239-1244.
24.Sukhotnik I, N. Shehadeh, J.Mogilner, R. Shamir, H.Helou, M.Lurie, E. Shiloni. Beneficial effects of oral insulin on intestinal recovery following ischemia- reperfusion injury in rat. J Surg Res 2005; 128:108-113.
25.Hatoum OA, Otterson MF, Kopelman D, Miura H, Sukhotnik I, Larsen BT, Selle RM, Moulder JE, Gutterman DD. Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species. Arterioscler Thromb Vasc Biol 2006; 26:287- 294.
26.Sukhotnik I, Vadasz Z, Coran AG, Lurie M, Shiloni E, Hatoum OA, Mogilner JG. Effect of leptin on intestinal re-growth following massive small bowel resection in rat. Pediatr Surg Int 2006; 22: 9-15.
27.Mogilner JG, Lurie M, Coran AG, Nativ O , Shiloni E, Sukhotnik I. Effect of diclofenac on germ cell apoptosis following testicular ischemia- reperfusion injury in a rat. Ped Surg Int 2006; 22: 99-105.
28.Sukhotnik I, Shehadeh N, Shamir R , Bejar J, Bernshteyn A, Mogilner JG. Oral insulin enhances intestinal re-growth following massive small bowel resection in rat. Dig Dis Sci 2005; 50:2379- 2385.
29.Mogilner J, Elenberg I, Lurie M, Shiloni E, Coran AG, Sukhotnik I. Effect of dexamethasone on germ cell apoptosis in the contralateral testis following testicular ischemia-reperfusion injury in the rat. Fertility and Sterility 2006; 85 Suppl 1:1111-1117.
30.Shehadeh N, Sukhotnik I, Shamir R. Gastrointestinal tract as a target organ for orally administered insulin. J Pediatr Gastroenterol Nutr 2006; 43:276-281. 10
31. Sukhotnik I, Bejar Y, Srugo I, Krausz MM, Bernshteyn A, Hirsh M, Mogilner JG. Adverse effect of increased intraabdominal pressure on small bowel structure and bacterial translocation in rat. J Laparoendosc Adv Surg Tech A. 2006; 16:404-410.
32.Sukhotnik I,Helou H, Lurie M, Khateeb K, Bejar J, Coran AG, Mogilner J, Shiloni E. The effect of leptin on intestinal recovery following ischemia-reperfusion injury in a rat. Ped Surg Int 2007; 23:473-478.
33. Sukhotnik I, Voskoboinik K, Lurie M, Coran AG, Greenblatt R, Shiloni E, Eldar S, Mogilner J. Effect of testicular ischemia-reperfusion on recruitment of neutrophils, E-selectin expression and germ cell apoptosis in the contralateral testis in a rat. Ped Surg Int, 2007; 23:479-485.
34.Sukhotnik I, Slijper N, Karry R, Shaoul R, Coran AG, Lurie M, Shiloni E, Mogilner JG. Bombesin stimulates enterocyte turnover following massive small bowel resection in a rat. Ped Surg Int 2007; 23:397-404.
35.Sukhotnik I, Khateeb K, Mogilner JG, Helou H, Lurie M, Coran AG, Shiloni E. Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following ischemia-reperfusion injury in the rat. Dig Dis Sci 2007; 52:1497-1504.
36.Sukhotnik I, Agam M, Shamir R, Shehadeh N, Lurie M, Coran A, Shiloni E, Mogilner J. Oral glutamine prevents gut mucosal injury and improves mucosal recovery following lipopolysaccharide endotoxemia in a rat. J Surg Res 2007; 143:379-384.
37.Mogilner J, Srugo I, Lurie M, Shaoul R, Coran AG, Shiloni E, Sukhotnik I. Effect of probiotics on intestinal re-growth and bacterial translocation following massive small bowel resection in a rat. J Pediatr Surg 2007; 42:1365-1371.
38. Sukhotnik I, Shehadeh N, Rothem L, Lurie M, Mogilner JG, Shiloni E, Shamir R. Effect of oral insulin on intestinal expression of toll-like receptor 4 and mucosal recovery following lpopolysaccharide-induced gut injury in a rat. Dig Dis Sci 2008; 53:1231-1239.
39.Sukhotnik I, Coran AG, Greenblatt R, Brod V, Mogilner J, Shiloni E, Shaoul R, Bitterman H. Effect of 100% oxygen on E-selectin expression, recruitment of neutrophils and enterocyte apoptosis following intestinal ischemia-reperfusion in a rat. Ped Surg International 2008; 24: 29- 35.
40.Sukhotnik I, Greenblatt R, Voskoboinik K, Lurie M, Coran AG, Mogilner JG. Relationship between time of reperfusion and E-selectin expression, neutrophil recruitment and germ cell apoptosis after testicular ischemia in a rat model. Fertility@Sterility 2008; 90: 1517-1522.
41. Sukhotnik I, Srugo I, Mogilner JG, Lurie M, Coran AG, Shiloni E, Shaoul R. Effect of lactulose on bacterial translocation and intestinal adaptation in a rat model of short bowel syndrome. JPGN J Pediatr Gastroenterol Nutr 2008;46:507-513.
42.Sukhotnik I, Meyer G, Nativ O, Coran AG, Voskoboinik K, Shiloni E, Mogilner JG. Effect of allopurinol on germ cell apoptosis following testicular ischemia-reperfusion in a rat. Ped Surg International 2008; 24: 61-66.
43.Sukhotnik I, Mogilner JG, Shaoul R, Karry R, Lieber M, Suss-Toby E, Ure BN, Coran AG. 11
Responsiveness of intestinal epithelial cell turnover to TGF-α after bowel resection in a rat is correlated with EGF receptor expression along the villus-crypt axis. Ped Surg International 2008; 24: 21-28.
44.Kessel A, Toubi E, Pavlotzky E, Mogilner J , Coran AG, Lurie M, Karry R, Sukhotnik I. Glutamine attenuates intestinal mucosal injury caused by LPS endotoxemia through down- regulation of TLR-4 and MyD88 expression. J Clin Exp Immunology 2008; 151:341-347.
45.Sukhotnik I, Shehadeh N, Coran AG, Mogilner J, Karry R, Shamian B, Ure BM, Shamir R. Oral insulin enhances cell proliferation and decreases enterocyte apopotosis during methotrexate- induced mucositis in a rat. J Pediatr Gastroenterol Nutr 2008; 47:115-122.
46. Sukhotnik I, Shteinberg D, Ben Lulu S, Bashenko Y, Mogilner JG, Lurie M, Ure B, Coran AG. Effect of transforming growth factor-alpha on eneterocyte apoptosis in correlated with EGF receptor expression along the villus-crypt axis during methotrexate-induced intestinal mucositis in a rat . Apoptosis 2008; 13:1344-1355.
47. Sukhotnik I, Shteinberg D, Ben Lulu S, Bashenko Y, Mogilner JG, Ure BM, Shaoul R, Shamian B, Coran AG. Transforming growth factor-alpha stimulates enterocyte proliferation and accelerates intestinal recovery following methotrexate-induced intestinal mucositis in a rat and a cell culture model. Ped Surg Internat 2008; 24:1303-1311.
48. Sukhotnik I, Hayari L, Bashenko Y, Chemodanov E, Mogilner J, Shamir R, Shaoul R, Coran AG. Dietary palmitic acid modulates intestinal re-growth after massive small bowel resection in a rat. Ped Surg Internat 2008; 24:1313-1321.
49. Sukhotnik I, Mogilner J, Hayari L, Brod V, Shaoul R, Slijper N, Bejar Y, Coran AG, Bitterman H. Effect of elevated intra-abdominal pressure and 100% oxygen on superior mesenteric artery blood flow and enterocyte turnover in a rat. Ped Surg Internat 2008; 24:1347-1353.
50. Mogilner J, Bitterman H, Hayari L, Brod V, Coran AG, Shaoul R, Lurie M, Eldar S, Sukhotnik I. Effect of elevated intra-abdominal pressure on portal vein blood flow, hepatocyte proliferation and apoptosis in a rat. Eur J Pediatr Surg 2008; 18:380-386.
51. Sukhotnik I, Mogilner J, Brod V, Hayari L, Coran AG, Shiloni E, Eldar S,
Bitterman H. Effect of elevated intra-abdominal pressure on portal vein and superior mesenteric artery blood flow in a rat. J Laparoendosc Adv Surg Tech 2009;19 Suppl 1:S59-62.
52. Sukhotnik I, Lieber M, Coran AG, Abassi Z, Shaoul R, Shiloni E, Mogilner JG. Bilirubin impairs intestinal re-growth following massive small bowel resection in a rat. J Pediatr Gastroenterol Nutr (JPGN) 2009; 49:16-22.
53. Sukhotnik I, Mogilner J, Karry R, Shamian B, Lurie M, Ure B, Kokhanovsky N, Coran AG. Effect of oral glutamine on enterocyte turnover during methotrexate-induced mucositis in a rat. Digestion 2009;79:5-13.
54. Sukhotnik I, Brod V, Lurie M, Rahat MA, Lahat N, Mogilner JG, Bitterman H. The effect of 100% oxygen on intestinal preservation and recovery following ischemia-reperfusion injury in rats. Crit Care Med 2009, 37:1054-1061. 12
55. Sukhotnik I, Mogilner JG, Shteinberg D, Karry R, Lurie M, Ure B, Shaoul R, Coran AG. Leptin accelerates enterocyte turnover during methotrexate-induced intestinal mucositis in a rat. Cancer Biol Ther 2009, 8: 1-7.
56. Sukhotnik I, Voskoboinik K, Lurie M, Bejar Y, Coran AG, Mogilner JG. Involvement of the bax and bcl-2 system in the induction of germ cell apoptosis is correlated with the time of reperfusion following testicular ischemia in a rat. Fertility&Sterility 2009; 92:1466-1469.
57. Sukhotnik I, Coran AG, Mogilner JG, Shamian B, Karry R, Lieber M, Suss-Toby E, Shaoul R. Leptin affects intestinal epithelial cell turnover in correlation with leptin receptor expression along the villus-crypt axis after massive small bowel resection in a rat. Pediatric Research 2009;66:648-653.
58. Ben Lulu S, Coran AG, Mogilner JG, Shaoul R, Shamir R, Shehadeh N, Sukhotnik I. Oral insulin stimulates intestinal epithelial cell turnover in correlation with insulin-receptor expression along the villus-crypt axis in a rat model of short bowel syndrome. Ped Surg International 2010; 26: 37-44.
59. Sukhotnik I , Slijper N, Chemodanov E, Bashenko Y, Shaoul R, Coran AG, Mogilner J. Effect of simvastatin on intestinal recovery following gut ischemia-reperfusion injury in a rat. Ped Surg International 2010; 26:105–110.
60. Sukhotnik I, Shany A, Bashenko Y, Hayari L, Chemodanov E, Mogilner J, Coran AG, Shaoul R. Parenteral but not enteral omega-3 fatty acids (omegaven) modulate intestinal re-growth after massive small bowel resection in a rat. JPEN J Parenter Enteral Nutr. 2010; 34:503-512.
61. Sukhotnik I, Mogilner JG, Ben Lulu S, Bashenko Y, Shaoul R, Chemodanov E, Coran AG. Nutritional supplementation with transforming growth factor-beta (TGF-β) inhibits intestinal adaptation after massive small bowel resection in a rat. Ped Surg International 2011 ;27:211-216.
62. Sukhotnik I, Slijper N, Chemodanov E, Bashenko Y, Shaoul R, Coran AG, Mogilner JG. Parenteral omega-3 fatty acids (Omegaven) modulate intestinal recovery following intestinal ischemia-reperfusion in a rat. J Pediatr Surg 2011,46:1353-1360.
63. Sukhotnik I, Shamir R, Bashenko Y, Mogilner KG, Chemodanov E, Shaoul R, Coran AG, Shehadeh N. Effect of oral insulin on diabetes-induced intestinal mucosal growth in a rat. Dig Dis Sci 2011; 56: 2566-2570.
64. Shaoul R, Mogilner J, Coran A, Chemodanov E, Sukhotnik I. Nutritional supplementation with transforming growth factor-beta (TGF-β) affects enterocyte turnover in correlation with TGF-β receptor expression after massive small bowel resection in a rat. Gastroenterology 2010, 138 (5 Supplement 1), p.S-705.
65. Sukhotnik I, Kuscuoglu U, Altindag B, Tao GZ, Lehwald N, Sylvester KG. Intestinal involvement during 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced chronic liver injury in a mouse model. J Pediatr Surg 2011; 46:1495-1502.
66. Ben Lulu S, Coran AG, Shehadeh N, Shamir R, Mogilner JG, Sukhotnik I. Oral insulin stimulates intestinal epithelial cell turnover following massive small bowel resection in a rat and a cell culture model. Pediatr Surg Int 2012; 28:179-187.
67. Sukhotnik I, Razon H, Pollak Y, Hayari L, Bejar J, Mogilner JG, Sylvester KG. Effect of alpha- naphthylisothiocyanate-induced liver injury on intestinal adaptation in a rat model of short bowel 13
syndrome. Pediatr Surg Int 2012; 28:161-169.
68. Koppelmann T, Pollak Y, Mogilner J, Bejar J, Coran AG, Sukhotnik I. Dietary L-arginine supplementation reduces methotrexate-induced intestinal mucosal injury in rat. BMC Gastroenterology 2012; 30;12:41 .
69. Koppelmann T, Pollak Y, Mogilner J, Bejar J, Coran AG, Sukhotnik I. Reversal of severe MTX- induced intestinal damage using enteral Omega-3 fatty acids. Br J Nutr 2012; 28:1-10.
70. Sukhotnik I, Mogilner J, Pollak Y , Blumenfeld S, Bejar J, Coran AG. Platelet-derived growth factor-alpha (PDGF-α) stimulates intestinal epithelial cell turnover after massive small bowel resection in a rat. American Journal of Physiology: GI & Liver 2012; 302:G1274-1281.
71. Sukhotnik I, Ben Lulu S, Pollak Y, Bejar J, Coran AG, Mogilner JG. Transforming growth factor-beta (TGF-β) affects enterocyte turnover in correlation with TGF-β receptor expression after massive small bowel resection in a rat. J Pediatr Gastroenterol Nutr (JPGN) 2012; 55:721- 727.
72. Ben-Lulu S, Pollak Y, Mogilner J, Bejar J, Coran AG, Sukhotnik I. Dietary transforming growth factor-beta 2 (TGF-β2) supplementation reduces methotrexate-induced intestinal mucosal injury in a rat. PLoS ONE 2012;7(9):e45221.
73. Sukhotnik I, Nativ O, Roitburt A, Bejar D, Coran AG, Mogilner JG, Nativ O. Methotrexate induces germ cell apoptosis and impairs spermatogenesis in a rat. Pediatr Surg Int 2013; 29:179-184.
74. Hadjittofi C, Coran AG, Mogilner JG, Pollak Y, Matter I, Sukhotnik I. Dietary supplementation with vitamin D stimulates intestinal epithelial cell turnover after massive small bowel resection in rats. Pediatr Surg Int 2013; 29:41-50. 75. Sohotnik R, Nativ O, Abbasi A, Awad H, Frajewicki V, Bishara B, Sukhotnik I, Armaly Z, Aronson D, Heyman SN, Nativ O, Abassi Z. Phosphodiesterase-5 inhibition attenuates early renal ischemia-reperfusion-induced acute kidney injury: assessment by quantitative measurement of urinary NGAL and KIM-1. Am J Physiol Renal Physiol 2013;304: F1099-1104. 76. Sukhotnik I, Swaid F, , Matter I, Berkowitz D, Hadjittofi C, Pollak Y, Lavy A. Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following acetic acid induced intestinal injury in rats. Nutr Metab (Lond). 2013;10: 53-60. 77. Sukhotnik I, Roitburt A, Pollak Y, Dorfman T, Matter I, Mogilner JG, Bejar J, Coran AG. Wnt/β-catenin signaling cascade down-regulation following massive small bowel resection in a rat. Pediatr Surg Int 2014; 30:173-180. 78. Sukhotnik I, Haj B, Shaoul R, Pollak Y, Coran AG, Bitterman A, Matter I. Effect of ozone on intestinal recovery following intestinal ischemia-reperfusion injury in a rat. Pediatr Surg Int 2014; 30:181-188. 79. Sukhotnik I, Pollak Y, Coran AG, Pilatov J, Bejar J, Mogilner JG, Berkowitz D. Glutamine attenuates the inhibitory effect of methotrexate on TLR signaling during intestinal chemotherapy-induced mucositis in a rat. Nutr Metab (Lond) 2014; 17;11:17-24. 80. Sukhotnik I, Geyer T, Pollak Y, Mogilner JG, Coran AG, Berkowitz D. The role of Wnt/β-catenin signaling in enterocyte turnover during methotrexate-induced intestinal mucositis in a rat. PLoS One 2014; 9(11):e110675. doi: 10.1371. 81. Sukhotnik I, Starikov A, Coran AG, Pollak Y, Sohotnik R, Shaoul R. Effect of ozone on intestinal epithelial homeostasis in a rat. Rambam Maimonides Med J, 2015; 6(1): e 0006.
Clinical Research
1. Seniutovich RV, Alekseenko AV, Gul’ko AM, Sukhotnik IG. Results of stomach resection in duodenal ulcer. Vrach Delo 1986; 6: 88-90.
2. Alekseenko AV, Sukhotnik IG, Shkande IuD, Seniutovich RV, Tarabanchuk VV. Use of physiotherapy in the treatment of trophic ulcers. Klin Khir 1988; 7:41-43.
3. Alekseenko AV, Iftodii AG, Tarabanchuk VV,Stoliar VF, Sukhotnik IG, Ivashchuk. Organization and effectivness of physiotherapy at a surgical department. Klin Khir 1990; 1:54-55.
4. Sukhotnik IG. Comparative effectiveness of using constant and alternating magnetic fields in the treatment of trophic ulcers. Vestn Khir Im II Grek 1990; 144: 123-124.
5. Yardeni D, Sukhotnik I, Palma L, Siplovich L. Percutaneous drainage of pancreatic pseudocyst in children. Harefuah 1992; 123: 390-392.
6. Amiel G, Sukhotnik I, Kawar B, Siplovich L. The use of N-Butyl-2-Cyanoacrylate in leective surgical incisions: longterm outcomes. J Am Coll Surg 1999; 189: 21-25.
7. Miron D, Sukhotnik I, Yardeni D, Kawar B, Siplovich L. Surgical complications of shigellosis in children. Pediatric Infectious Disease Journal 2000, 19: 898-899.
8. Slijper N, Sukhotnik I, Toubi A, Mogilner J. Critical validation of ultrasound Doppler in diagnosis of torsion of undescended testis. Isr Med Assoc J 2007; 9:99-101.
9. Mogilner J, Slijper N, Kandelis E, Sukhotnik I. The management of pediatric appendicitis: an opinion survey of Israeli pediatric surgeons. Harefuah 2007, 146:414-419.
10. Yarchi D, Cohen A, Umansky T, Adler S, Sukhotnik I, Shaoul R. Assessment of end tidal CO2 during pediatric and adult sedation for endoscopic procedures. Gastrointestinal endoscopy 2009, 69:877-882.
11. Shamir R, Kolacek S, Koletzko S, Tavori I, Bader D, Litmanovitz I, Flidel-Rimon O, Marks KA, Sukhotnik I, Shehadeh N. Oral insulin supplementation in pediatric short bowel disease. A pilot observational study. J Pediatr Gastroenterol Nutr JPGN 2009; 49:108-111.
12. Shaoul R, Sukhotnik I, Mogilner J. Hypnosis as an adjuvant treatment for children with inflammatory bowel disease. Journal of Developmental & Behavioral Pediatrics 2009; 30:268.
13. Sukhotnik I, Riskin A, Bader D, Lieber M, Shamian B, Mogilner JG. The possible importance of increased intraabdominal pressure in development of necrotizing enterocolitis. Eur J Pediatr Surg 2009;19:307-310.
14. Stermer E, Sukhotnik I, Shaoul R. Pruritus ani: an approach to an itching condition. J Pediatr Gastroenterol Nutr JPGN 2009; 48:513-516.
15. Levine A, Domanov S, Sukhotnik I, Zangen T, Shaoul R. Celiac-associated peptic disease at upper endoscopy: How common is it? Scand J Gastroenterol, 2009; 44:1424-1428.
16. Zion N, Chemodanov E, Levine A, Sukhotnik I, Bejar J, Shaoul R. The yield of a continuously patent gastroesophageal junction during upper endoscopy as a predictor of esophagitis in children. Dig Dis Sci 2010;55:3102-3107.
17. Dori N, Levi L, Stam T, Sukhotnik I, Shaoul R. Transient hyperphosphatasemia in children revisited. Pediatrics International 2010;52:866-871.
18. Somri M, Coran AG, Mattar I, Teszler C, Shaoul R, Tomkins O, Tome R, Mogilner JG, Sukhotnik I, Gaitini L. The postoperative occurrence of cardio-respiratory adverse events in small infants undergoing gastrointestinal surgery: a prospective comparison of general anesthesia and combined spinal-epidural anesthesia. Pediatr Surg Int 2011, 27:1173-1178.
19. Somri M, Coran AG, Hadjittofi C, Parisinos CA, Mogilner JG, Sukhotnik I, Gaitini L, Tome R, Matter I. Improved outcomes in paediatric anaesthesia: contributing factors. Pediatr Surg Int.2012;28:553-561.
20. Abassi Z, Shalabi A, Sohotnik R, Nativ O, Awad H, Bishara B, Frajewicki V, Sukhotnik I, Abbasi
A, Nativ O. Urinary NGAL and KIM-1: Biomarkers for assessment of acute ischemic kidneyinjury following nephron sparing surgery. J Urol. 2012; 18. doi:pii: S0022-5347(12)05257-3.
21. Steiner Z, Natan OB, Sukhotnik I, Coran AG, Keren G. Does Staphylococcus aureus nasal carriage require eradication prior to elective ambulatory surgery in children? Pediatr Surg Int 2014; 30:521-525.
Case reports
1. Sukhotnik I, Klin B, Siplovich L. Foreign- body appendicitis. J Pediatr Surg 1995; 30: 1515- 1516.
2. Sukhotnik I, Miron D, Yardeny D, Kawar B, Siplovich L. Perforated appendicitis in shigellosis:case report. IMAJ 1999; 1:124-125.
3. Shaoul R, Sukhotnik I, Toubi A. Neonatal sepsis as a choledochal cyst. Acta Paediatrica 2008; 97:246-249.
4. Toubi A, Sukhotnik I, Bejar J, Mogilner J, Shaoul R. Evolution of biliary atresia in early life. Eur J Pediatr Surg 2010; 20:128-130.
Review papers
1. Sukhotnik I, Krausz MM, Siplovich L, Shiloni E. Peptide growth factors and intestinal adaptation in short bowel syndrome. Isr Med Assoc J 2003 ;5:184-187.
2. Sukhotnik I, Bernshtein A, Mogilner JG. The basic biology of apoptosis and its implications for pediatric surgery.Eur J Pediatr Surg 2005;15:229-235.
3. Sukhotnik I, Coran AG, Kramer A, Shiloni E, Mogilner J. Advances in the research of the short bowel syndrome: un updated review. Ped Surg Int 2005; 21:947-953.
Invited review papers
1. Sukhotnik I, Rofe A. Germ cell apoptosis: clinical implications. Andrology-Open Access (in press). 2. Abbou B, Rofe A, Sukhotnik I. The world experience of pediatric intestinal failure program: successful outcomes from intestinal rehabilitation. HaRefuah (in press).
Chapters
1. Sukhotnik I. Short bowel syndrome. In "Gastrointestinal Disorders: Symptoms, Treatment and Prevention". Editor(s): Marouane Battik and Nesrine Grimaldi. Nova Publishers, 2012 pp71-112.
2. Sukhotnik I. Intestinal Mucosal Hypoplasia: Types, Risk Factors and Treatment Options. In " Advances in Medicine and Biology". Editor: Leon V.Berhardt. Nova Publishers, 2012, pp 91-112. 3. Sukhotnik I. Omega-3 Fatty Acids: Role in Intestinal Adaptation and Recovery. In " Omega-3 Fatty Acids: Chemistry, Dietary Sources and Health Effects" Editors: Wasim Khan. Nova Publishers, 2013, pp159-172. 4. Sukhotnik I. Short Bowel Syndrome: Definition, Incidence, Historical Overview, and Etiology. In "Short Bowel Syndrome in Children: Current Practice and Future Perspectives. Authors / Editors: Igor Sukhotnik. Nova Publishers, 2013, pp1-14. 5. Sukhotnik I. Short Bowel Syndrome: Pathophysiology and Intestinal Adaptation. In "Short Bowel Syndrome in Children: Current Practice and Future Perspectives. Authors / Editors: Igor Sukhotnik. Nova Publishers, 2013, pp 31-62. 6. Coran AG, Sukhotnik I. Mortality and Morbidity of Short Bowel Syndrome. In "Short Bowel Syndrome in Children: Current Practice and Future Perspectives. Authors / Editors: Igor Sukhotnik. Nova Publishers, 2013, pp 63-72. 7. Rofe A, Sukhotnik I. The World Experience of Pediatric Intestinal Failure Program: Successful Outcomes from Intestinal Rehabilitation. In "Short Bowel Syndrome in Children: Current Practice and Future Perspectives. Authors / Editors: Igor Sukhotnik. Nova Publishers, 2013, pp 131-142. 8. Sukhotnik I, Lemos PS. Right lower quadrant abdominal pain. In "Practical algorithms in pediatric gastroenterology". Editor: R.Shaoul. Karger, 2014, pp 68-69. 9. Finkel Y, Sukhotnik I. Short bowel syndrome. In "Practical algorithms in pediatric gastroenterology". Editor: R.Shaoul. Karger, 2014, pp 72-73. 10. Sukhotnik I. Parenteral omega-3 fatty acids (Omegaven) and intestinal recovery. In " Diet and Nutrition in Critical Care" Rajkumar Rajendram, Vinood B. Patel, Victor R. Preedy (eds.) Springer Publishers, 2015.
Books
Short Bowel Syndrome in Children: Current Practice and Future Perspectives. Authors / Editors: Igor Sukhotnik. Nova Publishers, 2013.
CONFERENCES
INTERNATIONAL AND NATIONAL MEETINGS-INVITED TALKS
1. XXXV International Congress of Physiological Sciences.
Iinvited talk, session "The nature of intestinal adaptation: cellular diversity and versality". San Diego, California, USA, 2005, April.
2. Annual National Pediatric Surgery Society Meeting.
Invited Talk. Short bowel syndrome- updates. Tel Aviv, Israel, 2011, December.
3. 2nd World Congress on Diabetes & Metabolism. Invited Talk. Diabetes and Intestinal Mucosal Homeostasis. Philadelphia, PA, USA, 2011, December.
4. 17th World Congress on Advances in Oncology. Invited Talk. Crasstolk between TLR signaling and intestinal stem cell activity during experimental chemotherapy-induced mucositis. Crete, Greece, 2012, October.
5. 18th World Congress on Advances in Oncology. Invited Talk. The role of Wnt/β-catenin signaling during intestinal recovery following chemotherapy-induced mucositis. 18th World Congress on Advances in Oncology. Crete, Greece, 2013, October.
6. 17th International Symposium on Molecular Medicine. Invited Talk. Wnt/β-catenin signaling is involved in stem cell decision during chemotherapy- induced intestinal mucositis in a rat model. Metropolitan Hotel, Athens, Greece, 2014 October.
INTERNATIONAL AND NATIONAL MEETINGS- CHAIRMAN
2010 Chairman
The 11th European Congress of Paediatric Surgery. Berne, Switzerland, June 5-8, 2010.
2011 Chairman The 12th European Congress of Paediatric Surgery. Barcelona, Spain, June 15-18, 2011.
2011 Chairman Session VIII. 24th International Symposium of Pediatric Surgical Research
Graz, Austria, September 8-10, 2011
2013 Chairman The 14th European Congress of Paediatric Surgery. Leipzig, Germany, June 2013.
2013 Chairman 18th World Congress on Advances in Oncology. Crete, Greece, 2013, October.
2014 Chairman 15th European Congress of Paediatric Surgery. Dublin, Ireland, 2014, June.
SEMINARS
2006, Feb Dept of Pediatric Surgery, Mott Children's Hospital, University of Michigan
"Advances in the research of short bowel syndrome"
2014, Oct National&Kapodistrian University of Athens Medical School, Attikon Hospital "Intestinal failure- new horizons"
CONTRIBUTED TALKS AND ABSTRACTS
1. Kokoshuk GI,Zajaeva VV,Mardar AI, Sukhotnik I. Acid-Base function of kidney as a part of common adaptations syndrome. VII Russian Congress of physiology of Kidney and Fluid- Electrolyte balance, Chernigov, Russia, 1985, October.
2. Brod V, Sukhotnik I,Balan M,Bitterman H.Hemodinamic effects of oxygen treatment in uncontrolled hemorrhagic shock. 22nd Congress of the National Shock Society, USA, 1998, June.
3. Bitterman H, Sukhotnik I, Balan M, Siplovich L, Brod V. Effects of oxygen in three models of uncontrolled hemorrhage. 24-th Annual Meeting of the European Underwater Baromedical Society on Diving and Hyperbaric Medicine, Stockholm, 1998, Aug .
4. Siplovich L, Kawar B, Yardeni D, Sukhotnik I. Abdominal compartment syndrome in children. 33rd European Congress of Pediatric Surgery, Brussels, Belgium, 1999, May.
5. Sukhotnik I, Yardeni D, Kawar B, Siplovich L. Neonatal surgery: operating room or neonatal intensive care unit? 21st National Congress of Surgery, Israel, 1999,May.
6. Sukhotnik I, May N, Coran AG, Drongovsky B, M.Harmon C. Effects of high fat diet on intestinal adaptation in a rat model of short bowel syndrome. Moses Gunn Annual Research Conference, Ann Arbor, Michigan. 2000, March.
7. Sukhotnik I, May N, Drongovski B, Coran AG, Harmon MC. Effect of high fat diet on lipid absorbability and concomitant plasma and tissue lipid content in a rat model of short bowel syndrome. APSA (American Pediatric Surgery Association) Annual Congress, Orlando, Florida. 2000, May.
8. Sukhotnik I, Gork AS, Drongovski B, Coran AG, Harmon MC. Effect of high fat diet on very early intestinal adaptation in a rat model of short bowel syndrome. AAP (American Academy of Pediatrics), Annual Congress, Chicago, 2000, October.
9. Sukhotnik I, Gork AS, Chen M, Drongovski B, Coran AG,Harmon M. Effect of high fat diet on CD36 expression in small bowel and long chain fatty acid uptake by isolated enterocyte in a rat model of short bowel syndrome. 86th Clinical Congress of the American College of Surgeons,Chicago. 2000, October.
10. Sukhotnik I, Gork AS, Chen M,Drongovski B, Coran AG,HarmonMC. Effect of low fat diet on CD36 expression in small bowel and long chain fatty acid uptake by isolated enterocyte in rats following bowel resection. Annual International Congress: Research in Pediatric Surgery, Ann Arbor, MI. 2000,November.
11. Sukhotnik I, Krausz M, Mannheim D, Hirsh M, Sabo E, Shiloni E. Endotoxemia inhibith intestinal adaptation in a rat model of short bowel syndrome. The 22nd Israel Surgical Federation National Congress, Tel Aviv, Israel. 2001, May.
12. Sukhotnik I, Yakirevich E, Krausz M, Kramer A, Mannheim D,Shiloni E. Low Fat Diet inhibits adaptation in a rat following bowel resection.The 22nd Israel Surgical Federation National Congress, Tel Aviv, Israel. 2001, May.
13. Geron N, Sukhotnik I, Eyal A, Vaysler A, Kremer A, Shiloni E. Stent insertion in treatment of large bowel obstruction. The 22nd Israel Surgical Federation National Congress,Tel Aviv, Israel. 2001, May.
14. Sukhotnik I, Krausz M, Hirsh M, Sabo E, Mannheim D, Shiloni E. Endotoxemia inhibits intestinal adaptation in a rat model of short bowel syndrome. 24th Annual Conference on Shock, Marco Island, Florida 2001, June.
15. Sukhotnik I, Yakirevich E, Kramer A, Sabo E, Krausz M, Harmon CM,Coran AG, Shiloni E. Low fat diet impairs post-resection intestinal adaptation in a rat. International Surgical Week, Brussel Belgium. 2001, August.
16. Sukhotnik I, Gork AS, Chen M, Drongovski B, Coran A, Harmon MC. Effect of bowel resection and high fat diet on myocardial CD36 expression in a rat model of short bowel syndrome. Annual International Congress: Research in Pediatric Surgery, Madrid, 2000, October.
17. Sukhotnik I, Yakirevich E, Coran AG , L.Siplovich, Kramer A, Sabo E, Krausz M, Shiloni E. Endotoxemia decreases cell proliferation and apoptosis during intestinal adaptation in a rat model of short bowel syndrome. Annual International Congress: Research in Pediatric Surgery, Madrid, 2001,October.
18. Sukhotnik I, Yakirevich E, Coran AG , L.Siplovich, Hirsh M , Sabo E, Krausz M, Shiloni E. Transforming growth factor-alpha increases enterocyte proliferation, decreases apoptosis and stimulates intestinal adaptation in a rat model of short bowel syndrome. British Association of Pediatric Surgery Annual Meeting, Cambridge, Great Britain, 2002, July.
19. Siplovich L, Sukhotnik I , Krausz MM, Coran AG, Shiloni E. Effect of enteral and parenteral arginine on enterocyte proliferation and apoptosis during postresection adaptation in a rat. Asian Association of Pediatric surgeons, Singapore, 2002, October.
20. Sukhotnik I, Sabo E, Krausz M, Lerner A, Siplovich L, Coran A, Shiloni E. Enteral arginine supplementation impairs post-resection intestinal adaptation in a rat. 15th International Symposium of Pediatric Surgical Research, Graz, Austria, 2002, November.
21. Sukhotnik I, Gork AS, Drongowski R, Coran AM, Harmon CM. Effect of high fat diet on lipid absorption and fatty acid transport in a rat model of short bowel syndrome. 15th International Symposium of Pediatric Surgical Research, Graz,Austria, 2002, November.
22. Sukhotnik I, Siplovich L, Krausz MM, Hirsh M, Resnick, Lerner A, Shiloni E. Parrenteral arginine supplementation inhibits intestinal adaptation during postresection intestinal adaptation in a rat. 18th World Congress of Digestive Surgery, Hong Kong 2002, December.
23. Sukhotnik I, Siplovich L, Krausz MM, Coran AG, Shiloni E. Comparison of enteral and parenteral arginine on enterocyte proliferation and apoptosis during post-resection intestinal adaptation in a rat. 18th World Congress of Digestive Surgery, Hong Kong 2002, December.
24. Sukhotnik I, Krausz M, Mogilner J, Siplovich L, Shiloni E. TGF-alpha stimulates intestinal adaptation in a rat model of shortbowel syndrome. The 23rd Israel Surgical Federation National Congress, Dead Sea, Israel. 2003, June.
25. Sukhotnik I, Mogilner J, Krausz M, Kramer A, Siplovich L, Shiloni E. Effect of arginine on structural adaptation in a rat following bowel resection. The 23rd Israel Surgical Federation National Congress, Dead Sea, Israel. 2003, June.
26. Hatib K, Sukhotnik I, Sabo E, Shiloni E. Sandostatin inhibits intestinal adaptation in a rat with short bowel syndrome. The 23rd Israel Surgical Federation National Congress, Dead Sea, Israel. 2003, June.
27. Sukhotnik I, Shiloni E, Krausz MM, Kramer A,Coran AG, Mogilner J. Effect of gender and sex hormones on structural intestinal adaptation following massive small bowel resection in a rat. 15th International Symposium of Pediatric Surgical Research, Marseille, France, 2003, October.
28. Sukhotnik I, Krausz MM, Shiloni E, Coran AG, Mogilner J. Oral arginine prevents gut mucosal injury caused by lipopolysaccharideendotoxemia in rat.15th International Symposium of Pediatric Surgical Research, Marseille, France 2003, October.
29. Sukhotnik I, Bachar Y, Srugo I, Krausz MM, Bernshteyn A, Hirsh M, Mogilner J. Effect of eleveted Intraabdominal Pressure on intestinal structure and bacterial translocation in rat.13th Annual Congress for Endosurgery in Children, Maui, Hawaii. 2004, May.
30. Sukhotnik I, Mogilner J, Shamir R, Shehadeh N, Bejar J, Hirsh M, Coran AG. Effect of subcutaneous insulin on intestinal adaptation in a rat model of short bowel syndrome. 17th International Symposium of Pediatric Surgical Research, Liverpool, UK, 2004, October.
31. Sukhotnik I, Helow H, Mogilner J, Lurie M, Bernsteyn A, Coran AG, Shiloni E. Oral Arginine Reduces Intestinal Mucosal Injury Caused by Ischemia- Reperfusion in Rat17th International Symposium of Pediatric Surgical Research, Liverpool, UK 2004, October.
32. Sukhotnik I, Miselevich I, Lurie M, Nativ O, Coran AG, Mogilner G. The time relationship between ipsilateral testicular ischemia-reperfusion and germ cell apoptosis in the contralateral testis in rat. 17th International Symposium of Pediatric Surgical Research, Liverpool, UK 2004, October.
33. Sukhotnik I (Invited talk). Oral insulin enhances intetsinal regrowth following massive small bowel resection in rat. XXXV International Congress of Physiological Sciences, San Diego, California 2005, April.
34. J.Mogilner, Sukhotnik I, N. Shehadeh, R. Shamir, H.Helou, M.Lurie,E. Shiloni Effect of oral insulin on intestinal recovery following ischemia-reperfusion injury in rat. 14th Annual Congress for Endosurgery in Children, Venice, Italy ,2005, May.
35. Shamir R, Sukhotnik I, Shehadeh N. Oral Insulin enhances intestinal adaptation in a rat model of short bowel syndrome. 38th Annual Meeting of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition, Porto, Portugal, 2005, June.
36. Helow H, Sukhotnik I, Mogilner J, Lurie M, Shiloni E. Oral arginine reduces intestinal mucosal injury caused by ischemia- reperfusion in rat. The 24th Israel Surgical Federation National Congress, Dead Sea, Israel, 2005, June.
37. Sukhotnik I, Mogilner J, Shamir R, Shehadeh N, Shiloni E. Oral insulin enhances intetsinal regrowth following massive small bowel resection in rat.The 24th Israel Surgical Federation National Congress, Dead Sea, Israel, 2005, June.
38. Helou H, Shiloni E, Mogilner J, Shehadeh N, Shamir R, Lurie M, Sukhotnik I. Effectof oral insulin on intestinal recovery following ischemia- reperfusion injury in rat. The 24th Israel Surgical Federation National Congress, Dead Sea, Israel. 2005, June.
39. Sukhotnik I, Vadasz Z, Coran AG, Lurie M, Shiloni E, Hatoum OA, Mogilner JG. Leptin stimulates intestinal re-growth following massive small bowel resection in a rat. 18th International Symposium of Pediatric Surgical Research, Stockholm, Sweden 2005, September.
40. Sukhotnik I, Brod V, Lurie M, Mogilner JG, Bitterman H. The effect of 100% oxygen on intestinal recovery following ischemia- reperfusion injury in a rat. 18th International Symposium of Pediatric Surgical Research Stockholm, Sweden, 2005, September.
41. Sukhotnik I, Lurie M, Coran AG, Nativ O, Mogilner JG. Effect of diclofenac on germ cell apoptosis following testicular ischemia-reperfusion in a rat.18th International Symposium of Pediatric Surgical Research Stockholm, Sweden, 2005, September.
42. Sukhotnik I, Slijper N, Karry R, Shaoul R, Coran AG, Lurie M, Shiloni E, Mogilner JG. Bombesin stimulates enterocyte turnover following massive small bowel resection in a rat. 19th International Symposium of Pediatric Surgical Research, Florence, Italy, 2006, October.
43. Sukhotnik I, Helou H, Lurie M,Coran AG, Mogilner JG, Shiloni E. The effect of leptin on intestinal recovery following ischemia-reperfusion injury in a rat. 19th International Symposium of Pediatric Surgical Research, Florence, Italy, 2006, October.
44. Sukhotnik I, Voskoboinik K, Lurie M, Bejar J,Coran AG, Shiloni E, Mogilner JG Effect of testicular ischemia-reperfusion on recruitment of neutrophils, E-selectin expression and germ cell apoptosis in a rat. 19th International Symposium of Pediatric Surgical Research,Florence, Italy 2006, October.
45. Mogilner JG, Greenblatt R , Voskoboinik K, Lurie M, Sukhotnik I. Relationship between time of reperfusion and recruitment of neutrophils, E- selectin expression and germ cell apoptosis in a rat model of testicular ischemia. IPEG's Annual Congress, Argentina, 2007,September.
46. Sukhotnik I, Mogilner JG, Shaoul R, Karry R, Lieber M, Suss-Toby E,Ure BN, Coran AG. Responsiveness of intestinal epithelial cell turnover to TGF- α after bowel resection in a rat is correlated with EGF receptor expression along the villus-crypt axis. 20th International Symposium of Pediatric Surgical Research Bern, Switzerland 2007, October.
47. Sukhotnik I, Coran AG, Greenblatt R, Brod V, Mogilner J, Shiloni E, Shaoul R, Bitterman H. Effect of 100% oxygen on E-selectin expression, recruitment of neutrophils and enterocyte apoptosis following intestinal ischemia-reperfusion in a rat. 20th International Symposium of Pediatric Surgical Research, Bern, Switzerland, 2007, October.
48. Sukhotnik I, Meyer G, Nativ O, Coran AG, Voskoboinik K, Shiloni E, Mogilner JG. Effect of allopurinol on germ cell apoptosis following testicular ischemia-reperfusion in a rat. 20th International Symposium of Pediatric Surgical Research, Bern, Switzerland, 2007, October.
49. Sukhotnik I, Srugo I, Mogilner JG, Lurie M, Coran AG, Shiloni E, Shaoul R. Effect of lactulose on bacterial translocation and intestinal adaptation in a rat model of short bowel syndrome. 93rd Clinical Congress of American College of Surgeons, New Orleans, USA, 2007, October.
50. Mogilner J, Sukhotnik I, Brod V, Hayari L, Coran AG, Shiloni E, Eldar S, Bitterman H. Effect of elevated intra-abdominal pressure on portal vein and superior mesenteric artery blood flow in a rat. 17th Annual Congress of Endosurgery in Children, Cannes, France, 2008, June.
51. Sukhotnik I, Mogilner J, Brod V, Hayari L, Coran AG, Bitterman H. Effect of elevated intraabdominal presssure and hyperoxia on portal vein blood flow, hepatocyte proliferation and apoptosis in a rat. 9th European Congress of Pediatric Syrgery, Istanbul, Turkey 2008, June.
52. Sukhotnik I, Mogilner J, Hayari L, Brod V, Shaoul R, Slijper N, Shiloni E, Coran AG, Bitterman H. Effect of elevated intra-abdominal pressure (IAP) and 100% oxygen on superior mesenteric artery (SMA) blood flow and enterocyte turnover in a rat. 21st International Symposium of Pediatric Surgical Research, Leipzig, Germany 2008, October.
53. Sukhotnik I, Shteinberg D , Ben Lulu S, Bashenko Y, Mogilner JG, Ure BN, Shaoul R, Coran AG. Transforming growth factor-alpha stimulates enterocyte proliferation and accelerates intestinal recovery following methotrexate-induced intestinal mucositis in a rat and a cell culture model. 21st International Symposium of Pediatric Surgical Research, Leipzig, Germany, 2008, October.
54. Hayari L, Sukhotnik I, Bashenko Y, Mogilner J, Shaoul R, Chemodanov E, Eldar S, Coran AG. Dietary palmitic acid modulates intestinal re-growth after massive small bowel resection in a rat . 21st International Symposium of Pediatric Surgical Research, Leipzig , Germany 2008, October.
55. Sukhotnik I, Coran AG, Lurie M, Mogilner JG, Benhoor Shamian, Shiloni E, Shaoul R. Leptin affects intestinal epithelial cell turnover in correlation with leptin receptor expression along the villus-crypt axis after massive small bowel resection in a rat. 94th Clinical Congress of American College of Surgeons, San Francisco, USA, 2008, October.
56. Ben Lulu S, Coran AG, Mogilner JG, Shaoul R, Shamir R, Shehadeh N, Sukhotnik I.Oral insulin stimulates intestinal epithelial cell turnover in correlation with insulin-receptor expression along the villus-crypt axis in a rat model of short bowel syndrome. 22nd International Symposium of Pediatric Surgical Research, Genova, Italy, 2009 September.
57. Sukhotnik I , Slijper N, Chemodanov E, Bashenko Y, Shaoul R, Coran AG, Mogilner J. Effect of simvastatin on intestinal recovery following gut ischemia-reperfusion injury in a rat. 22nd International Symposium of Pediatric Surgical Research, Genova, Italy, 2009, September.
58. Sukhotnik I, Shany A, Bashenko Y, Hayari L, Chemodanov E, Mogilner J, Coran AG, Shaoul R. Parenteral but not enteral omega-3 fatty acids (omegaven) modulate intestinal re-growth after massive small bowel resection in a rat. Clinical Congress of American College of Surgeons, Chicago, USA, 2009, October.
59.Mogilner JG, Slijper N, Chemodanov E, Bashenko E, Shaoul R, Coran AG, Sukhotnik I. Parenteral omega-3 fatty acids modulated intestinal recovery following intestinal ischemia- reperfusion in a rat. The 11th European Congress of Paediatric Surgery, Berne Switzerland, 2010, June.
60. Sukhotnik I, Mogilner JG, Ben Lulu S, Bashenko Y, Shaoul R, Chemodanov E, Coran AG. Nutritional supplementation with transforming growth factor-beta (TGF-β) inhibits intestinal adaptation after massive small bowel resection in a rat. 22nd International Symposium of Pediatric Surgical Research, Tokyo, 2010, September.
61. Mogilner JG, Slijper N, Chemodanov E, Bashenko Y, Shaoul R, Coran AG, Sukhotnik I. Parenteral omega-3 fatty acids (Omegaven) modulate intestinal recovery following intestinal ischemia-reperfusion in a rat. 22nd International Symposium of Pediatric Surgical Research, Tokyo, 2010, September.
62. Shaoul R, Mogilner J, Coran A, Chemodanov E, Sukhotnik I. Nutritional supplementation with transforming growth factor-beta (TGF-β) affects enterocyte turnover in correlation with TGF-β receptor expression after massive small bowel resection in a rat. Digestive Disease Week, New Orleans,USA, 2010, May.
63. Sukhotnik I, Pollak Y, Blumenfeld S, Bejar J, Coran AG, Mogilner J. Platelet-derived growth factor-alpha (PDGF-α) stimulates intestinal epithelial cell turnover after massive small bowel resection in a rat. 12th European Congeress of Pediatric Surgery, Barcelona, 2011, June.
64. Slijper N , Matter I, Mogilner JG, Bashenko Y, Sukhotnik I. Parenteral omega-3 fatty acids (Omegaven) modulate intestinal recovery following intestinal ischemia-reperfusion in a rat. The 27th Israel Surgical Federation National Congress, Jerusalem, Israel. 2011, June.
65. Sukhotnik I, Pollak Y, Slijper N, Matar I, Mogilner J. Platelet-derived growth factor-alpha (PDGF-α) stimulates intestinal epithelial cell turnover after massive small bowel resection in a rat. The 27th Israel Surgical Federation National Congress, Jerusalem, Israel. 2011, June.
66. Sukhotnik I, Hayari L, Pollak Y, Razon H, Bejar J, Mogilner J, Sylvester KG. Effect of alpha-naphthylisothiocyanate induced liver injury on intestinal adaptation in a rat model of short bowel syndrome. 24thInternational Symposium of Pediatric Surgical Research, Graz, Austria, 2011, September.
67. Ben Lulu S, Coran AG, Shehadeh N, Mogilner JG, Shamir R, Sukhotnik I. Oral insulin stimulates intestinal epithelial cell turnover following massive small bowel resection in a rat and a cell culture model. 24thInternational Symposium of Pediatric Surgical Research, Graz, Austria, 2011, September.
68. Slijper N, Sukhotnik I, Mogilner JG. Appendectomy for complicated appendicitis in children– Laparoscopic or Open? EUPSA/BAPS joint meeting, Rome, 2012, June.
69. Sukhotnik I, Ben Lulu S, Pollak Y, Bejar J, Coran AG, Mogilner JG. Transforming growth factor-beta (TGF-β) affects enterocyte turnover in correlation with TGF-β receptor expression after massive small bowel resection in a rat. EUPSA/BAPS joint meeting, Rome, 2012, June.
70. Hadjittofi C, Coran AG, Mogilner JG, Pollak Y, Bejar J, Sukhotnik I. Dietary supplementation with vitamin D stimulates intestinal epithelial cell turnover after massive small bowel resection in a rat 25th International Symposium of Pediatric Surgical Research, London, 2012, September.
71. Sukhotnik I, Nativ O, Roitburt A, Mogilner JG, Coran A, Nativ O. Methotrtexate induces germ cell apoptosis and impairs spermatogenesis in rat testes. 25th International Symposium of Pediatric Surgical Research, London, 2012, September.
72. Sukhotnik I, Pollak Y, Bejar J, Coran AG, Mogilner JG. Notch signaling cascade is implicated in the control of stem cell activities after massive small bowel resection in a rat model. The 14th European Congress of Paediatric Surgery. Leipzig, Germany, 2013, June.
73. Sukhotnik I. Invited Talk. The role of Wnt/β-catenin signaling during intestinal recovery following chemotherapy-induced mucositis. 18th World Congress on Advances in Oncology. Crete, Greece, 2013, October.
74. Haj B, Sukhotnik I, Shaoul R, Pollak Y, Coran AG, Matter I. Effect of ozone on intestinal recovery following gut ischemia-reperfusion injury in a rat. 26th International Symposium of Pediatric Surgical Research, Cape Town, 2013, November. 75. Sukhotnik I, Roitburt A, Pollak Y, Matter I, Bejar J, Mogilner JG, Coran AG. Wnt/beta-catenin signaling is down-regulated two weeks after massive small bowel resection in a rat model. 26th International Symposium of Pediatric Surgical Research, Cape Town, 2013, November. 76. Sukhotnik I, Matter I, Roitburt A, Pollak Y, Dorfman T, Mogilner JG, Coran AG. Crosstalk between Wnt/beta-catenin and Notch signaling in the control of stem cell activity after massive small bowel resection in a rat model. 15th European Congress of Pediatric Surgery. Dublin, Ireland, 2014, June. 77. Sukhotnik I, Roitburt A, Mogilner J, Berkowitz D. Role of WNT/beta-catenin signaling cascade during intestinal adaptation in a rat model of short bowel syndrome. 47th Annual Meeting of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition. Jerusalem, Israel, 2014. June. 78. Sukhotnik I. Wnt/β-catenin signaling is involved in stem cell decision during chemotherapy- induced intestinal mucositis in a rat model. 17th International Symposium on Molecular Medicine Metropolitan Hotel, Athens, Greece, 2014, October. 79. Sukhotnik I, Roitburt A, Pollak Y, Mogilner JG, Hayari L, Coran AG. Signaling involved in intestinal cell fate decision following massive small bowel resection in a rat model. American College of Surgeons 2014 Clinical Congress, San Francisco, CA, 2014, October.